Product Description

Quinine Sulphate (6119-70-6)

Quinine sulphate is a medication that has been used for centuries to treat malaria. It is derived from the bark of the cinchona tree, which is native to South America. Quinine sulphate works by interfering with the growth and reproduction of the malaria parasites in the body. It does this by disrupting the parasite’s ability to make ATP, which is a molecule that provides energy for the parasite. Quinine sulphate is also thought to damage the parasite’s cell membrane, which can lead to the parasite’s death.

Quinine sulphate is an effective treatment for malaria, but it can also have side effects, such as nausea, vomiting, and diarrhoea. In some cases, quinine sulphate can also cause more serious side effects, such as liver damage and hearing loss. For this reason, quinine sulphate should only be used under the supervision of a doctor.

In addition to treating malaria, quinine sulphate is also used to treat nocturnal leg cramps. Nocturnal leg cramps are involuntary muscle contractions that occur in the legs while a person is sleeping. Quinine sulphate is thought to work by relaxing the muscles and preventing them from contracting. However, quinine sulphate is not a first-line treatment for nocturnal leg cramps, and it should only be used if other treatments have not been effective.

Here are some additional information about quinine sulphate:

  • Dosage: The dosage of quinine sulphate will vary depending on the patient’s age, weight, and medical condition.
  • Side effects: The most common side effects of quinine sulphate are nausea, vomiting, and diarrhoea. In some cases, quinine sulphate can also cause more serious side effects, such as liver damage and hearing loss.
  • Interactions: Quinine sulphate can interact with a number of other medications, including antibiotics, anticonvulsants, and heart medications.
  • Overdose: Quinine sulphate overdose can be fatal. If you think you or someone you know has overdosed on quinine sulphate, call 911 or the Poison Control Center immediately.

Identification

Molecular Formula   :     C40H50N4O8S, 2H2O

Cas No.                       :     6119-70-6

Regulatory Documents

USDMF                      :     

EDMF                         :     

Batch Size                 :     300 Kgs.

Specifications

Appearance   :     White or almost white, crystalline powder or fine, colorless needles.

Solubility

Slightly soluble in water, sparingly soluble in boiling water and in ethanol (96 %)

Specific Optical Rotation   :     -237° to -245°C at 20°C

Loss On Drying                   :     3.0 % to 5.0 %

pH                                         :     5.7 to 6.6

Sulfated ash                        :     Not more than 0.10%

Assay

Quinine Sulfate   :     99.0 % to 101.0 % (dried substance)

Chromatographic purity By HPLC

Dihydroquinine ( impurity C)                                   :     ≤ 10.0%

Any related substance Eluted before quinine      :     ≤ 5.0 %

Any other related substance                                   :     ≤ 0.80 %